Sofosbuvir and daclatasvir
نویسندگان
چکیده
After entering hepatocytes, the viral genome of the hepatitis C virus (HCV) is translated into a single polypeptide. This polypeptide is subsequently cleaved into viral proteins, including non-structural (NS) proteins NS3, NS4A, NS5B and NS5B RNA dependent RNA polymerase (Figure 1) [3, 4]. These viral proteins are essential for viral replication and assembly making them significant targets for therapy. Sofosbuvir is the first available inhibitor of NS5B RNA dependent RNA polymerase. Daclatasvir is an inhibitor of NS5B.
منابع مشابه
Rapid reductions in prices for generic sofosbuvir and daclatasvir to treat hepatitis C
OBJECTIVES Novel treatments for hepatitis C demonstrate high cure rates, but current high prices can be a barrier to rapid global treatment scale-up. Generic competition can rapidly lower drug prices. Using data on exports of raw materials in 2015, we calculated currently feasible generic prices of sofosbuvir and daclatasvir. METHODS Data on per-kilogram prices of sofosbuvir and daclatasvir a...
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